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#PostCovid

13 posts6 participants2 posts today
Public
ahimsa

Using the Ryan White HIV/AIDS Program as a blueprint to help Long Covid patients

healthaffairs.org/content/fore

"As the COVID-19 pandemic enters its fifth year, the number of individuals experiencing persistent and debilitating symptoms consistent with postacute sequalae of COVID-19 or Long COVID continues to impact more than 44 million Americans and impair their activity levels."

(many new ME/CFS cases have been triggered by COVID)

@longcovid

#Covid19#LongCovid#PostCovid
Public
Tom Kindlon

From Sweden:

Post #COVID19 among young adults– prevalence & associations with general health, stress, & lifestyle factors

bmcpublichealth.biomedcentral.

"Almost 4% of young adults with previous self-reported #COVID_19 had ongoing symptoms of PCC 3 years after the onset of the pandemic”

@longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #PASC #postcovid #CovidBrain
@covid19 #COVID #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver #auscovid19 @auscovid19

BioMed CentralPost COVID-19 among young adults– prevalence and associations with general health, stress, and lifestyle factors - BMC Public HealthBackground The prevalence of post COVID-19 condition (PCC) after mild infection among young adults is largely unknown, as are its impact on health and lifestyle factors. Objective To assess the prevalence of PCC among young adults and its impact on general health, stress, and changes in lifestyle factors three years after the onset of the pandemic. Methods The study population (n = 2,098) included participants from the population-based cohort BAMSE (aged 27–30 years). PCC symptoms and changes in lifestyle factors during the pandemic were assessed in a questionnaire distributed in September–December 2023 and analyzed cross-sectionally. Stress, physical activity, and general health were also assessed pre-pandemic (2016–2019) and analyzed longitudinally. PCC was defined as ≥ 1 symptom lasting for ≥ 2 months after COVID-19. Results In total, 1,577 (75.5%) reported previous COVID-19. Among these, 166 (10.5%) reported previous and 62 (3.9%) ongoing PCC. The most common ongoing symptoms were altered smell/taste, psychological symptoms, and fatigue. Both pre- and post-pandemic general health differed significantly in relation to PCC in cross-sectional analyzes (all p < 0.05), with the lowest health reported by those with ongoing PCC. Participants with ongoing PCC also had a reduction in well-being in longitudinal analyses (p = 0.04). This group also reported more adverse changes in lifestyle factors and health during the pandemic such as reduced physical activity (p < 0.001) and worsened dietary habits (p = 0.03). However, there was no significant difference in the longitudinally measured perceived stress scale among individuals with PCC. Conclusions Almost 4% of young adults with previous self-reported COVID-19 had ongoing symptoms of PCC three years after the onset of the pandemic. This group reported poorer health and more adverse changes in lifestyle factors than participants without PCC. Targeted healthcare interventions for young adults with PCC are warranted.
Public
Tom Kindlon

Proteomic Analysis of 442 Clinical Plasma Samples From Individuals With Symptom Records Revealed Subtypes of Convalescent Patients Who Had #COVID19

onlinelibrary.wiley.com/doi/10

"study identified [complement proteins] remain highly expressed 12 months after #SARSCoV2 infection"

@longcovid
#LongCovid #PwLC #PostCovidSyndrome #PASC #postcovid
#CovidBrain
@covid19 #COVIDー19 #COVID #COVID_19 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver #auscovid19 @auscovid19

Public
Tom Kindlon

Associations of epigenetic aging & #COVID19: A 3-year longitudinal study

link.springer.com/article/10.1

"#COVID_19 infection significantly increased the speed of aging assessed by DNAmGrimAge, DNAmGrimAge2, & DNAmFitAge compared to non-infected subjects during the 3 years”

@longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #PASC #postcovid
#CovidBrain
@covid19 #COVIDー19 #COVID #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver #auscovid19 @auscovid19

SpringerLinkAssociations of epigenetic aging and COVID- 19: A 3-year longitudinal study - GeroScienceAging and COVID- 19 are known to influence DNA methylation, potentially affecting the rate of aging and the risk of disease. The physiological functions of 54 volunteers—including maximal oxygen uptake (VO₂ max), grip strength, and vertical jump—were assessed just before the COVID- 19 pandemic and again 3 years later. Of these volunteers, 27 had contracted COVID- 19. Eight epigenetic clocks were used to assess the rate of aging during the 3-year period: DNAmAge showed accelerated aging, and five clocks showed slowed aging (DNAmAgeSkinBlood, DNAmAgeHannum, DNAmFitAge, PhenoAge, and DNAmTL). When we considered only females, we observed a stronger effect in the increase of DNAmAge acceleration, while we observed slowed aging in the case of SkinBloodClock, and DNAmTL. The methylation of the promoter region of the H1 FNT genes, which encodes testis-specific histone H1 family member N (H1fnt) and plays a crucial role in spermatogenesis decreased the most significantly. In contrast, the promoter of CSTL1, which encodes Cystatin-like 1, showed the most significant increase. We found that having COVID- 19 during the 3-year study period significantly increased the progress of aging assessed by DNAmGrimAge, DNAmGrimAge2, and DNAmFitAge (p = 0.024, 0.047, 0.032, respectively, after we adjusted the analysis for baseline variables). The data suggest that COVID- 19 may have a mild long-term effect on epigenetic aging.
Public
Tove Harris 2. Account

PolyBio-supported study reveals long-term immune and metabolic damage after COVID-19 infection

"New preprint study reveals profound and long-lasting biological disruptions that can follow a SARS-CoV-2 infection, including changes connected to altered metabolism and cancer-associated epigenetic changes."

polybio.org/polybio-supported-

PolyBio Research Foundation · PolyBio-supported study reveals long-term immune and metabolic damage after COVID-19 infection - PolyBio Research FoundationNew preprint study reveals profound and long-lasting biological disruptions that can follow a SARS-CoV-2 infection, including changes connected to altered metabolism...
#COVID#COVID19#Corona
Public
Tom Kindlon

#LongCovid #PASC

From the Netherlands:

Health outcomes up to 3 years ...

"Specifically, while some health outcomes improved over time, self-reported fatigue and cognitive problems worsened between the second and third year."

thelancet.com/journals/lanepe/

Image is from latest Science for ME weekly update

@longcovid
#PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #SARSCoV2 #CovidIsNotOver

The Lancet Regional Health – Europe Health outcomes up to 3 years and post-exertional malaise in patients after hospitalization for COVID-19: a multicentre prospective cohort study (CO-FLOW) — Julia C. Berentschot et al. "In this multicentre prospective cohort study with follow-up up to 3 years after hospitalization for COVID-19, the findings showed that patient experienced persisting and even worsening of several health issues up to 3 years. Specifically, while some health outcomes improved over time, self-reported fatigue and cognitive problems worsened between the second and third year."
Public
Tom Kindlon

"the results from this analysis suggest among people who were tested for #COVID19, those with a positive test experienced an increased rate of diagnosis of infectious illnesses in the 12 months following"

thelancet.com/journals/laninf/

Image is from latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID #COVID_19 #COVIDー19 #SARSCoV2
@auscovid19 #auscovid19

The Lancet Infectious Diseases Rates of infection with other pathogens after a positive COVID-19 test versus a negative test in US veterans (November, 2021, to December, 2023): a retrospective cohort study — Miao Cai et al. "the results from this analysis suggest that among people who were tested for COVID-19, those with a positive test experienced an increased rate of diagnosis of infectious illnesses in the 12 months following"
Public
Tom Kindlon

ICU participants' hospitalisation conferred them status as legitimate patients in ‘medically clear and understandable ways’ whereas LC participants' ‘patienthood’ was neither evidenced nor authenticated"
onlinelibrary.wiley.com/doi/10

Image is from latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2

Health Expectations Rethinking ‘Recovery’: A Comparative Qualitative Analysis of Experiences of Intensive Care With COVID and Long Covid in the United Kingdom — Alice MacLean et al. "Key differences in ‘worlds of illness’ stemmed from the fact that ICU participants' hospitalisation conferred them status as legitimate patients in ‘medically clear and understandable ways’ whereas LC participants' ‘patienthood’ was neither evidenced nor authenticated in the same way."
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