#ProxLB - the #LoadBalancer for #Proxmox just got released in version 1.0.5.
ProxLB adds features like #DRS from #VMware, node evacuation etc. to Proxmox and is fully #opensource
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#PMx
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Huh
So I went through all that trouble finding out how to get a #fbx (without using #Blender or #CATS plugin - despite how good it may be)
to realize:
#Sketchfab has:
* limited uploads
* displays #static models (not sure if I could embed an #animation
* sigh
Srsly ?
My own #webrender split off can do more than that
https://alceawis.de/mmdlatest.html
What a waste of time
BLEH !
#DisappontedAo
The processin on #sketchfab takes forever too.
Are they struggling with my #pmx / #mmd ik bone names ?
So I went through all that trouble finding out how to get a #fbx (without using #Blender or #CATS plugin - despite how good it may be)
to realize:
#Sketchfab has:
* limited uploads
* displays #static models (not sure if I could embed an #animation
* sigh
Srsly ?
My own #webrender split off can do more than that
https://alceawis.de/mmdlatest.html
What a waste of time
BLEH !
#DisappontedAo
The processin on #sketchfab takes forever too.
Are they struggling with my #pmx / #mmd ik bone names ?
Replied to Justin Wilkins
@justinwilkins As for general #Pmx applications, were you aware of Vijay Ivaturi's https://pumas.ai/ ?
Pumas-AIPumas-AIPharmaceutical Modeling and Simulation
Replied to David C. Norris 
@dcnorris This sounds juicy. Care to expand? #JuliaLang has been on the radar a while now but I have yet to see a compelling #Pmx application
Replied in thread
For those interested, there are lots of journals that publish in #PMx, including
- Journal of Pharmacokinetics and Pharmacodynamics (JPKPD)
- Clinical Pharmacology and Therapeutics: Pharmacometrics and Systems Pharmacology (CPT:PSP)
- The AAPS Journal (AAPS J)
The International Society of Pharmacometrics (#ISoP) is the professional scientific association for #PMx. I was a member of its Board of Directors, and it's one of the most fun and rewarding things I've done.
ISoPISoP
Replied in thread
Modeling tools in our area are largely closed-source and massively expensive, and are a gigantic entry barrier for new people, especially in low and middle-income countries (and borderline unaffordable even for CROs like mine). #nlmixr2 is intended to be a solution to this problem. I also maintain the #pmxTools package, which provides a handy set of general #PMx functions.
www.nlmixr2.orgNonlinear Mixed Effects Models in Population PK/PDFit and compare nonlinear mixed-effects models in differential
equations with flexible dosing information commonly seen in pharmacokinetics
and pharmacodynamics (Almquist, Leander, and Jirstrand 2015
<doi:10.1007/s10928-015-9409-1>). Differential equation solving is
by compiled C code provided in the rxode2 package
(Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
Replied in thread
I promised you #Beer! It's actually a pretty good example. PK describes what happens to the alcohol (ethanol) you consume between the glass and the bathroom, and PD describes what it does while it's circulating in your blood (quite a few things, including making you tipsy). Ethanol is a pretty interesting case, because it's eye-wateringly complex. The #DrinkMe simulation on Nick Holford's website is a fun interactive example of how it fits together! #PMx
holford.fmhs.auckland.ac.nzEthanol PKPD
Continued thread
Wikipedia defines #Pharmacometrics (#PMx) as a field of study of the methodology and application of #models for disease and pharmacological measurement. It applies mathematical models of #biology, #pharmacology, #disease, and #physiology to describe and quantify interactions between #xenobiotics (drugs) and patients (human and non-human), including both beneficial and adverse effects.