Social.coop @SocialCoop

**PLOS Biology** @PLOSBiology@fediscience.org · 4h

PLOS Biology @PLOSBiology@fediscience.org

#Hippocampus & #PFC interact to support spatial #WorkingMemory, but are dHPC & vHPC functionally redundant in this? This study shows that both regions contribute differentially to spatial WM & coding of spatial info by PFC @PLOSBiology https://plos.io/4cXyddO

Top left: Schematic of virus injection and optic fiber implantation in dHPC (left) or vHPC (right) with electrodes implanted in the PFC to record neuronal activity during hippocampal silencing. Right: Example coronal sections showing ArchT-GFP expression in dHPC (top) and vHPC (bottom) with optic fiber placements outlined by dashed white lines. Bottom left: Task schematic. In the sample phase (left), mice were guided to enter one of the two goal arms to receive a reward. After a delay phase in the start box (middle), mice could choose between both goal arms but only received a reward in the goal arm opposite to the one visited in sample (right).

**Bytes Europe** @byteseu@pubeurope.com · 2d

**Albert Cardona** @albertcardona@mathstodon.xyz · Apr 9

**El Duvelle Neuro** @elduvelle_neuro@neuromatch.social · Apr 4

Apr 4

El Duvelle Neuro @elduvelle_neuro@neuromatch.social

I keep going back to this question about #TemporalCreditAssignment and #HippocampalReplay:
As an "agent" you want to learn the value of places and which places are likely to lead to reward;

-1) if a place leads to higher than expected reward, you'll want to propagate back the reward info from the reward throughout the places that led to the reward. If replay does that you should see an increase of replay at a new reward site and the replay sequences should start at the reward and reflect what you just did to reach it. Right?

-2) if a place leads to lower than expected reward, you'll also want to propagate that lowered value, pretty much in the same way, so if replay does that you should see a similar replay rate and content for increased OR decreased reward sites. Right?

-3) if a place has had unchanged reward for a while and you're just in exploitation mode (just going there again and again because you know that's the best place to go to in the environment) then you shouldn't need to update anything and replay rate should be quite low at that unchanged reward side. Right?

That's not at all what replay is doing IRL, so does that mean replay is not used for temporal credit assignment? Or did I (very likely) miss something?

#Neuroscience #ComputationalNeuroscience #DecisionMaking

**PLOS Biology** @PLOSBiology@fediscience.org · Apr 4

Apr 4

PLOS Biology @PLOSBiology@fediscience.org

Are hippocampal representations of other people anchored to #SelfKnowledge? This study shows other people’s preferences are represented relative to personal preferences in the #hippocampus & dorsomedial prefrontal cortex when retrieving relational social knowledge @PLOSBiology https://plos.io/449XRcD

Egocentric anchoring-and-adjustment in the hippocampal formation. Top: Neural and behavioral representational dissimilarity matrices (RDMs) for the general linear model (GLM) searchlight analysis for one representative participant. The neural RDM was used as a dependent variable with six predictor behavioral variables. These six variables were the absolute distance between the stranger’s rating and the ratings of the groups that are being compared with the stranger (absolute distance, AD), the differences between self and others’ preferences (rating discrepancy, RD, with either groups or individuals), the cognitive demand of how far the stranger’s preference is away from the individual’s rating (rescaling), and the memory for self and others’ preferences (rating consistency, RC, for groups or individuals). Middle: Group activation maps for self vs. group rating discrepancy (RDgroup). Bottom right: Beta coefficients of RSA GLM in ROI of dmPFC. Bars showing beta coefficients resulting from the GLM for each behavioral variable in the dmPFC, where there is a significant dmPFC effect for RDgroup (t(19) = 2.92, p = 0.008). Each dot represents an individual participant.

**John Vaccaro (johniac)** @johniac@mastodon.social · Mar 28

**El Duvelle Neuro** @elduvelle_neuro@neuromatch.social · Mar 27

Mar 27

El Duvelle Neuro @elduvelle_neuro@neuromatch.social

#PlaceCells often have elongated place fields next to an environment's boundaries.
Is there any paper where this phenomenon is directly predicted by the #SuccessorRepresentation model of place cells?

#SpatialCognition #Neuroscience #Hippocampus

**John Vaccaro (johniac)** @johniac@mastodon.social · Mar 24

**Science Media Center Germany** @smc_germany@sciencemediacenter.social · Mar 21

**John Vaccaro (johniac)** @johniac@mastodon.social · Mar 21

**El Duvelle Neuro** @elduvelle_neuro@neuromatch.social · Mar 21

Mar 21

El Duvelle Neuro @elduvelle_neuro@neuromatch.social

Thinking about #PlaceCells and the #Hippocampus, do you think results in rats (/rodents) generalise well to humans, and conversely?

25%Yes, good generalisation between the species
19%No, poor generalisation between the species
13%It depends (on what?)
44%I don't know / see results

#Neuroscience #NeuroRat #NeuroHuman

**John Vaccaro (johniac)** @johniac@mastodon.social · Mar 15 *

**CITO Greenhouse** @cito_greenhouse@mastodon.social · Mar 6

**CITO Greenhouse** @cito_greenhouse@mastodon.social · Feb 22

**PsyPost** @PsyPost@mstdn.social · Feb 14

**knizer** @knizer@toot.boston · Feb 7 *

**This Is My Glasgow** @thisismyglasgow@mastodon.scot · Feb 6 *

Feb 6 *

This Is My Glasgow @thisismyglasgow@mastodon.scot

One of the Clyde Street entrances to the Briggait in Glasgow. Designed by Clarke and Bell, it was oginally built in 1873 as a fish market. The hippocampi on either side of the central parapet are amongst the most distinctive architectural sculptures in the city.

An ornate entrance to a former fish market topped by a pediment with the hippocapmus sculptures on it.

#glasgow #architecture #hippocampus

**El Duvelle Neuro** @elduvelle_neuro@neuromatch.social · Feb 3

**El Duvelle Neuro** @elduvelle_neuro@neuromatch.social · Jan 28

Jan 28

El Duvelle Neuro @elduvelle_neuro@neuromatch.social

@johnwidloski and I are co-organizing a symposium on #HippocampalReplay at the #EBBS25 in Bordeaux!

Our goal: From the state of the art in awake replay models & existing data, determine the next big questions and most informative future experiments to finally figure out what is awake replay for!

Our speakers:

John Widloski
Lisa Genzel
Jacob Bakermans
Elisa Massi

Meeting dates: 28 June to 1 July 2025 (our symposium is on the last day

Programme: https://ebbs2025.azuleon.org/programme

The abstract submission deadline for posters (and early bird registration) is on 31 March 2025 - I hope to see you there!

ebbs2025.azuleon.orgEBBS 2025 :: ProgrammeThe website of the 51st EBBS Meeting :: EBBS 2025

#Neuroscience #NeuroSymp #NeuroConf

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