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(((Cindy Weinstein)))A HS student emailed me out of the blue to do an interview as part of her capstone project on <a href="https://zirk.us/tags/Alzheimer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Alzheimer</a>'s. I spoke w/her about <a href="https://zirk.us/tags/brain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#brain</a> science & <a href="https://zirk.us/tags/caregiving" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#caregiving</a>. She's 18, her family has the <a href="https://zirk.us/tags/APOE4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#APOE4</a> gene - a risk factor for the disease - & she will study neuroscience to find a cure for Alzheimer's. She's smart, determined, & I had chills listening to her story and her passion. The senseless, fascistic <a href="https://zirk.us/tags/NIH" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NIH</a> cuts are imperiling the potential, the future of people like her, & our own.<a href="https://zirk.us/tags/EndAlz" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EndAlz</a> <a href="https://zirk.us/tags/USPol" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#USPol</a>

(((Cindy Weinstein)))A HS student emailed me out of the blue to do an interview as part of her capstone project on <a href="https://mastodon.world/tags/Alzheimer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Alzheimer</a>'s. I spoke w/her about <a href="https://mastodon.world/tags/brain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#brain</a> science & <a href="https://mastodon.world/tags/caregiving" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#caregiving</a>. She's 18, her family has the <a href="https://mastodon.world/tags/APOE4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#APOE4</a> gene - a risk factor for the disease - & she will study neuroscience to find a cure for Alzheimer's. She's smart, determined, & I had chills listening to her story and her passion. The senseless, fascistic <a href="https://mastodon.world/tags/NIH" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NIH</a> cuts are imperiling the potential, the future of people like her, & our own.<a href="https://mastodon.world/tags/EndAlz" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EndAlz</a> <a href="https://mastodon.world/tags/USPol" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#USPol</a>

Victoria Stuart 🇨🇦 🏳️‍⚧️/1On the same (general) topic: individual genetic susceptibility ...Genes known to increase the risk of Alzheimer's may actually be an inherited form of the disorder, researchers say <a href="https://www.ctvnews.ca/health/genes-known-to-increase-the-risk-of-alzheimer-s-may-actually-be-an-inherited-form-of-the-disorder-researchers-say-1.6943195" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.ctvnews.ca/health/genes-known-to-increase-the-risk-of-alzheimer-s-may-actually-be-an-inherited-form-of-the-disorder-researchers-say-1.6943195</a> <a href="https://www.nytimes.com/2024/05/06/health/alzheimers-cause-gene-apoe4.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.nytimes.com/2024/05/06/health/alzheimers-cause-gene-apoe4.html</a>APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease <a href="https://www.nature.com/articles/s41591-024-02931-w" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.nature.com/articles/s41591-024-02931-w</a><a href="https://mastodon.social/tags/Alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Alzheimers</a> <a href="https://mastodon.social/tags/APOE4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#APOE4</a> <a href="https://mastodon.social/tags/genetics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#genetics</a>

Benjamin Carr, Ph.D. 👨🏻‍💻🧬Study Suggests <a href="https://hachyderm.io/tags/Genetics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Genetics</a> as a Cause, Not Just a Risk, for Some <a href="https://hachyderm.io/tags/Alzheimer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Alzheimer</a>’s People with two copies of the <a href="https://hachyderm.io/tags/gene" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#gene</a> variant <a href="https://hachyderm.io/tags/APOE4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#APOE4</a> are almost certain to get Alzheimer’s, say researchers, who proposed a framework under which such <a href="https://hachyderm.io/tags/patients" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#patients</a> could be diagnosed years before symptoms. <a href="https://www.nytimes.com/2024/05/06/health/alzheimers-cause-gene-apoe4.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.nytimes.com/2024/05/06/health/alzheimers-cause-gene-apoe4.html</a> <a href="https://archive.ph/yTtsM" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://archive.ph/yTtsM</a>

LupposofiA long-awaited AlzForum's take on the news that ApoE4 homozygotism means in fact an AD pathology (though not necessarily dementia before death), <a href="https://www.alzforum.org/news/research-news/do-two-apoe4-alleles-always-mean-alzheimers" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.alzforum.org/news/research-news/do-two-apoe4-alleles-always-mean-alzheimers</a>The comments-section gives a glimpse of some of the trenchlines regarding the treatment of dementia, but I guess the prevention-camp has only just been strirred up from their Sleeping Beauty's slumber.I, as an example, still have only a 1 % measured risk of acquiring AD, according to some widely used screens, and no "preventable risk factors" except maybe age. Too bad, my genetic inheritance seems to have been enough to skew the Amyloid-Beta balance early on. Luckily, I was recruited to the aducanumab-study for four years (a precursor of lecanemab with more severe side-effects), and probably got some more years to be able to think things like these.<a href="https://mementomori.social/tags/alzheimer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#alzheimer</a> <a href="https://mementomori.social/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#research</a> <a href="https://mementomori.social/tags/medical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#medical</a> <a href="https://mementomori.social/tags/APOE4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#APOE4</a> <a href="https://mementomori.social/tags/alzForum" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#alzForum</a> <a href="https://mementomori.social/tags/dementia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#dementia</a> <a href="https://mementomori.social/tags/ad" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ad</a> <a href="https://mementomori.social/tags/alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#alzheimers</a> <a href="https://mementomori.social/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#amyloid</a> <a href="https://mementomori.social/tags/lecanemab" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#lecanemab</a> <a href="https://mementomori.social/tags/aducanumab" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#aducanumab</a> <a href="https://mementomori.social/tags/prevention" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#prevention</a> <a href="https://mementomori.social/tags/cure" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cure</a>

DrBob, Neurologist, 🧠MechanicAlzheimer’s disease seen in near 100% APOE4 homozygotes“Findings revealed that almost all APOE4 homozygotes exhibited AD pathology and had significantly higher levels of AD biomarkers from age 55 compared to <a href="https://vmst.io/tags/APOE3" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#APOE3</a> homozygotes.By age 65, nearly all had abnormal amyloid levels in cerebrospinal fluid, and 75% had positive <a href="https://vmst.io/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#amyloid</a> scans, with the prevalence of these markers increasing with age, indicating near-full penetrance of AD biology in <a href="https://vmst.io/tags/APOE4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#APOE4</a> homozygotes”<a href="https://vmst.io/tags/Alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Alzheimers</a> <a href="https://vmst.io/tags/Dementia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Dementia</a> <a href="https://pbs.twimg.com/media/GM524u1bEAAJoAl.jpg" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pbs.twimg.com/media/GM524u1bEAAJoAl.jpg</a>

Science Media Center GermanyDie Genvariante <a href="https://sciencemediacenter.social/tags/APOE4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#APOE4</a> ist nicht nur Risikofaktor für <a href="https://sciencemediacenter.social/tags/Alzheimer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Alzheimer</a> sondern könnte laut einer Studie in Nature Medicine eine genetische Form der Erkrankung sein. Unabhängige Forschende finden die Ergebnisse überzeugend: <a href="https://www.sciencemediacenter.de/alle-angebote/research-in-context/details/news/apoe4-vom-risikogen-zur-genetischen-alzheimer-erkrankung/?mtm_campaign=mastodon&mtm_kwd=apoe4-vom-risikogen-zur-genetischen-alzheimer-erkrankung" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.sciencemediacenter.de/alle-angebote/research-in-context/details/news/apoe4-vom-risikogen-zur-genetischen-alzheimer-erkrankung/?mtm_campaign=mastodon&mtm_kwd=apoe4-vom-risikogen-zur-genetischen-alzheimer-erkrankung</a>

Bill LoguidiceSelect cases of Alzheimer's may be linked to carrying two copies of a gene in new research <a href="https://techhub.social/tags/alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#alzheimers</a> <a href="https://techhub.social/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#research</a> <a href="https://techhub.social/tags/study" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#study</a> <a href="https://techhub.social/tags/memorycar" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#memorycar</a> <a href="https://techhub.social/tags/dementia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#dementia</a> <a href="https://techhub.social/tags/gene" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#gene</a> <a href="https://techhub.social/tags/apoe4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#apoe4</a> <a href="https://techhub.social/tags/genetics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#genetics</a> <a href="https://techhub.social/tags/dna" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#dna</a><a href="https://fullsteamahead365.com/2024/05/07/alzheimers-may-be-linked-to-two-copies-of-gene/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://fullsteamahead365.com/2024/05/07/alzheimers-may-be-linked-to-two-copies-of-gene/</a>

joe•iuculano :mastodon:Via <a href="https://masto.ai/tags/ABC" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ABC</a> NewsScientists have long known a <a href="https://masto.ai/tags/gene" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#gene</a> called <a href="https://masto.ai/tags/APOE4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#APOE4</a> is one of many things that can increase people’s risk for <a href="https://masto.ai/tags/Alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Alzheimers</a>, including simply getting older. The vast majority of Alzheimer’s cases occur after age 65. But <a href="https://masto.ai/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#research</a> published Monday suggests that for people who carry not one but two copies of the gene, it's more than a risk factor, it's an underlying cause of the mind-robbing <a href="https://masto.ai/tags/disease" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#disease</a>.<a href="https://masto.ai/tags/Science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Science</a><a href="https://abcnews.go.com/Health/wireStory/subset-alzheimers-cases-caused-copies-single-gene-new-109957914" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://abcnews.go.com/Health/wireStory/subset-alzheimers-cases-caused-copies-single-gene-new-109957914</a>

MEActNOWPeople with 2 copies of APOE4 were known to have a high risk of <a href="https://mastodon.social/tags/Alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Alzheimers</a>. 📍Today that changed to nearly 100% full penetrance<a href="https://mastodon.social/tags/NatureMed" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NatureMed</a> 🔶 <a href="https://mastodon.social/tags/Alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Alzheimers</a> 🔶 <a href="https://mastodon.social/tags/APOE4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#APOE4</a>🔗 <a href="https://www.nature.com/articles/s41591-024-02931-w" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.nature.com/articles/s41591-024-02931-w</a>

CDCastilloBuenas noticias, nueva avenida terapéutica para prevenir el desarrollo de la Enfermedad de <a href="https://mastodon.cloud/tags/Alzheimer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Alzheimer</a>, incluso (sobre todo) en portadores de <a href="https://mastodon.cloud/tags/ApoE4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ApoE4</a>En los próximos años habrá nuevos intentos de tratamiento, excelentes noticias!<a href="https://pubmed.ncbi.nlm.nih.gov/38598053/" rel="nofollow noopener noreferrer" target="_blank">https://pubmed.ncbi.nlm.nih.gov/38598053/</a>

deutrinodear lazyweb please advise <a href="https://mstdn.io/tags/statins" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#statins</a> <a href="https://mstdn.io/tags/statin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#statin</a> <a href="https://mstdn.io/tags/dementia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#dementia</a> <a href="https://mstdn.io/tags/apoe4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#apoe4</a>

deutrinoI was not aware of this previously, but it's thought <a href="https://mstdn.io/tags/APoE4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#APoE4</a> was the only common APoE allele until fairly recent in hominid evolution, despite it seeming to be disadvantageous today

Hwamee OhPredictors of longitudinal cognitive ageing from age 70 to 82 including <a href="https://mastodon.online/tags/APOEe4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#APOEe4</a> status, early-life and <a href="https://mastodon.online/tags/lifestyle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#lifestyle</a> factors: the Lothian Birth Cohort 1936APOE4 status explains the majority of variance in cognitive aging (but not much in a verbal domain) when early-life and lifestyle factors are included in the same model.(Open Access) <a href="https://www.nature.com/articles/s41380-022-01900-4" rel="nofollow noopener noreferrer" target="_blank">https://www.nature.com/articles/s41380-022-01900-4</a><a href="https://mastodon.online/tags/CognitiveAging" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CognitiveAging</a> <a href="https://mastodon.online/tags/Apoe4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Apoe4</a> <a href="https://mastodon.online/tags/earlylifefactors" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#earlylifefactors</a> <a href="https://mastodon.online/tags/lifestyle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#lifestyle</a>

beSpacific<a href="https://mastodon.social/@philshapiro" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@philshapiro</a> NIH Study reveals how APOE4 gene may increase risk for dementia - women are at higher risk of inheriting this gene from each parent thus increasing the risk by 8 to 10 times. <a href="https://www.nih.gov/news-events/nih-research-matters/study-reveals-how-apoe4-gene-may-increase-risk-dementia" rel="nofollow noopener noreferrer" target="_blank">https://www.nih.gov/news-events/nih-research-matters/study-reveals-how-apoe4-gene-may-increase-risk-dementia</a> <a href="https://newsie.social/tags/Dementia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Dementia</a> <a href="https://newsie.social/tags/APOE4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#APOE4</a> <a href="https://newsie.social/tags/gene" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#gene</a> Take <a href="https://newsie.social/tags/Cholinesupplements" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cholinesupplements</a>

Muninn 🍃Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins. PLoS One. 2016 Nov 8;11(11):e0166195.<a href="https://www.ncbi.nlm.nih.gov/pubmed/27824936" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.ncbi.nlm.nih.gov/pubmed/27824936</a>Bleeding-edge research into how one might pharmacologically manage <a href="https://social.coop/tags/Alzheimers" class="mention hashtag" rel="tag">#Alzheimers</a> pathology in <a href="https://social.coop/tags/APoE4" class="mention hashtag" rel="tag">#APoE4</a> brains yields striking positive results in mice. <a href="https://social.coop/tags/ABCA1" class="mention hashtag" rel="tag">#ABCA1</a> <a href="https://social.coop/tags/dementia" class="mention hashtag" rel="tag">#dementia</a> <a href="https://social.coop/tags/neuroscience" class="mention hashtag" rel="tag">#neuroscience</a> <a href="https://social.coop/tags/brainscience" class="mention hashtag" rel="tag">#brainscience</a> <a href="https://social.coop/tags/RandomJournalArticles" class="mention hashtag" rel="tag">#RandomJournalArticles</a>

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