The Science Behind #CBD Dosing for #Anxiety and Other Conditions
CBD’s medicinal efficacy might require a particular dose range. Intriguingly, this Goldilocks Zone differs for each disorder.
[...The] lowest dose had a moderate anti-anxiety effect, the second-lowest dose had the greatest anti-anxiety effect, the third dose had a moderate effect, and the highest dose had no effect.
It's frustrating that the article doesn't say much about specific CBD doses, but that's understandable - the science is just starting to come out in many cases. I'm quite interested in this topic and will continue to post information on CBD dosing and administration methods as it becomes available.
I'll drop a link or two to some raw science in this thread for now.
Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life
"[S]ubjective anxiety measures were reduced with CBD 300 mg, but not with CBD 100 and 900 mg, in the post-speech phase."
Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425583/
Study: Nearly 70% of online #CBD marijuana extracts are mislabeled
Of 84 products tested:
* 31% were accurately labeled
* 42% had more CBD than was on the label
* 26% had less
* Vape liquid was least accurate, with only 12.5% accurate and 75% containing more CBD than described.
For some applications, too high a dose can reduce effectiveness. Expand this thread for links.
An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies (2017)
* favorable safety profile of #CBD in humans was generally confirmed
* most studies were for treatment of #epilepsy and psychotic disorders
* compared to existing #drugs for those disorders, side effects are milder
* more research needed on metabolic effects, drug interactions, and long term use
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569602/
#pharmacology #medicalmarijuana