Most people, clinicians included, have only a vague understanding of what means. They assume it equates to hyperactivity and poor focus, mostly in children. They are wrong.

When we take a step back... three defining features of ADHD emerge that explain every aspect of the condition:

* an interest-based nervous system
* emotional hyperarousal
* rejection sensitivity

(I'm nursing a hunch that ADHD can develop into type II when exposed to particular environments. It's not a super strong hunch at this point but it's definitely there.)

@muninn "Stimulant medications are very good at keeping people with ADHD from getting distracted once they are engaged, but they do not help you get engaged in the first place."

One of those things you read and feel that you have discovered a truth that you both knew and did not realize.

@kurtm So true. I do find that the right ADHD med increases the chance that I'll see a quick task (pile of laundry, unpaid bill, etc) and get it done right away instead of "oh crap I need to remember to do that" and immediately forget to do it, but as for the bigger more important tasks, it is still very difficult to get started. But once I get going I will stick to it longer before wandering away.

@muninn Wow this is pretty onpoint, especially that description of physical pain whenever I experience something even remotely related to rejection. Never really saw an explanation of that before.

@mathuin Yeah - in certain circumstances for me rejection causes a powerful sensation kinda like my chest is hollowed out and about to cave in, and like I'm very cold but without the shivers. Sometimes I'll get goosebumps and all my hairs stand on end. It's kind of amazing really, considering that the cue is usually just words.

@muninn Hope i'm not being too nosy, but do you also get tired some short time afterward?

@muninn or the lack of words, like feeling alone in a grpup because you just happen to not be engaged in a conversation. You know it has nothing to do with you, you just had a big conversation, but still that pain

@muninn I have not been diagnosed with ADHD, but there are things mentioned in the article that I can relate to, so it's curious to read about it. Thanks for sharing.

@muninn article seems to be describing obsessive interest ASD along with odd response to social situations. Fits my view of how ADHD & Autism overlap.

"Social impairments in autism spectrum disorder are related to maternal immune history profile."

I had a guess that RSD symptoms may be serotonin related... both medications they suggest are fingered as modulating serotonin thru action on alpha 2-adrenoceptors. Going on list of stuff to research. :) #actuallyautistic

@muninn My mom has all sorts of immune problems, so its interesting to think that my little brother's ADHD diagnosis may be a result of the same kind of process that lead to me being autistic. makes me wonder if the brain changes I suspect in me would mirror what shows up in ADHD in regards to how those two medications help. Thanks for sharing, it seem really insightful.

@ultimape Yeah, the genetic overlap between some neurological / mental health issues is interesting too. ADHD clusters with a number of other disorders in genome-wide association studies, and it's not the only one. It would be interesting to see if some of the "hardware" changes in ADHD can be pushed by the environment to develop into additional problems. I'm glad you found it interesting. I will be posting more hard research here in the future :)

@muninn @ultimape and to counter that: ADHD is no diagnosis. its a thrown-together, cooked up "cure all" collecting ponf, which most of the time is diagnosed based on check marks on a clipboard. So do NOT use it as a base for any kind of hypothesis.

@muninn @ultimape further crashing that hypothesis: my mom never had any sorts of immune problems. neither does my dad, nor anyone in the grandparent generation.

@ginsterbusch @muninn yeah, i'd much rather have direct brain scans and per-symptom scores along with a gene test and possibly a microbiome assay over a clipboard diagnosis.

I just got my 23andMe back to confirm a bunch of autism genes because I wasn't confident that even a diagnosis is really meaningful.

I'm a fan of computational psychiatry myself.
"... is mechanistic in a way that the DSM-5, ICD-10 and biopsychosocial model can never be"

@muninn @ginsterbusch The immune system issue seems to be only one of a myrid of risk factors. Its relevant to my personal version of it. But It's been fun watching the DSM deteriorate as the old classifications are starting to dissolve in light of more rigorous information.

@ginsterbusch @muninn I have a laundry list of things that can also manifest with ADHD and Autism symptoms including diet issues during pregnancy and stuff like fetal oxygen deprivation that have nothing to do with immune system problems, but still affect the brain's growth patterns during early development. It gets really hard to tease a part.

@muninn @ultimape then try adding "birth issue"("Geburtsfehler") to the list. It usually the euphemism for "the monitoring doctor commited some crap" in hospital speak in Germany. this might have led to my sight impairment, which is the main "cause"(in combination with MCD) of triggering (how I hate that word) my focus / concentration loss.

@muninn @ultimape in addition: my parents both have mild forms of sight impairment. all of my siblings do have that mild form (including those not of the same wife; patchwork family), even my preterm born sister (we both are of the same parents, the others aint). I am the only one with a more severe form of sight impairment.

@ginsterbusch @muninn ah, thanks for the word. The fetal oxygen deprivation one is a "Geburtsfehler" - the umbilical cord wraps around the neck. But I've also heard that 'Meconium aspiration' can be a risk factor - the baby inhales fluid because they weren't removed from the womb fast enough. Anything that puts pressure on the skull (e.g. pulling too hard with the forceps) can seem to cause similar.

ADHD is definitely a catch all in that sense - describes the observed symptoms, not the cause.

@muninn @ultimape AFAIR my mother said there was nothing wrong with the birth process itself, but must have happened right afterwards. In German hospitals, a doctor to at least take a look is mandatory. could have been some slight mishandling because of inexperience .. nobody knows exactly, though.

@ultimape Cross-referencing my 23andme raw data with pharmacogenomic research is the entire reason I have this Mastodon account, BTW. I am working to set up a blog that digs into such issues, and created this account because I haven't followed through yet and figured the social media tie-in would be motivating, and it is, but I still don't have the blog up πŸ˜‚

@muninn Thanks for the link! All this hits close to home. Some of it too close.

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