I saw elsewhere - perhaps Twitter - a criticism of the #cyberpunk idea, reflected in Cyberpunk 2077, that the unaltered human body is somehow sacred, and that augmenting it is profane. The criticism noted that this was, at its core, transphobic.
The critic then turned the idea on its head into a trans-positive cyberpunk that eschewed "humanity" in favor of "essence". Maybe one person's essence is complete when they're born; maybe another's essence is lacking until they augment themselves.
@noelle
There's a rich seam here in early European science/occult, too: the ultimate goal of alchemy, the "philosopher's stone", was the transmutation of the self. Presumed spiritually, as it came with gnostic overtones of a maliciously concealed higher truth. But the acceptance that self-change through external technologies can bring you closer to your true self? :)